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- Nano Network
R.T. Jones Professor of Structural Biology, Oregon Health Sciences University
Michael Chapman is a biophysicist interested in the mechanics and interactions of bio-macromolecular assemblies, and how they might be manipulated rationally. His group uses x-ray crystallography, together with electron microscopy, NMR spectroscopy, molecular biology, biochemical kinetics and computer modeling to study the role of enzyme dynamics in catalysis, and viral-host interactions important in the delivery of DNA to cells. A particular interest is Adeno-Associated Virus (AAV), a human non-pathogenic virus, whose atomic structure was determined by the group, providing a roadmap for those manipulating the cellular specificity of genetically-engineered vectors used to deliver DNA in experimental gene therapies for inherited diseases.