- Economic Impact
- Nano Network
Associate Professor of Biology, University of Oregon
We are interested in how an organism adapts to the physiological challenges of daily life and what this tells us about the physiological and developmental responses to disease in humans. The particular challenge we study is the response to low oxygen. When faced with inadequate oxygen (hypoxia), animals undergo a series of transient and longer-term changes to increase their access to oxygen and decrease their need for it. If oxygen homeostasis is not restored, death or serious tissue damage can result. In humans, serious pathology can also result when the hypoxic responses are inappropriately activated, as in rapidly proliferating tumors that turn on hypoxia-response programs that promote tumor angiogenesis and growth.