Researchers
Andrew H. Marcus
Associate Professor, University of Oregon
Thrusts
NanoBiotechnology/NanoMedicine, Nanoscale Metrology and Nanoelectronics
Background and Research Interests
B.A., University of California, San Diego, 1987. Ph.D., Stanford University, 1994 (Michael D. Fayer). Postdoctoral: University of Chicago, James Franck Institute, 1994-96 (Stuart A. Rice). Honors and Awards: Research Corporation Innovation Award, 1997; NSF CAREER Award, 1998. Innovative Polymer Research Lecturer, Materials Science and Engineering Laboratory, National Institute of Standards and Technology, 2001. At Oregon since 1996.
The Marcus group is interested in the dynamics of complex systems, including the structure-function of bio-molecular species in the cytoplasm of living cells. To study intracellular processes, we have developed novel fluorescence-based optical techniques to probe center-of-mass motions and internal structural changes of fluorescently labeled organelles, proteins and nucleic acids in their native environment. Fourier imaging correlation spectroscopy (FICS) is a low-signal imaging method designed to probe organelle transport, in addition to macromolecular conformational transition pathways (1). Fluorescence-detected two-dimensional coherence spectroscopy is an important method to study the details of local macromolecular conformation by detecting exciton coupling between chromophore labeled sites (2).
Selected Publication
- Senning, E. N.; Marcus, A. H. “Subcellular Dynamics and Protein Conformation Fluctuations Measured by Fourier Imaging Correlation Spectroscopy,” Ann. Rev. Phys. Chem., 2010, 61, 111-28, currently in press and online.
- Tekavec, P. F.; Lott, G. A.; Marcus, A. H. “Fluorescence-Detected Two-Dimensional Electronic Coherence Spectroscopy by Acousto-Optic Phase Modulation,” J. Chem. Phys. 2007, 127, 214307-1-21.
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